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Randomized Controlled Trial

Berger V, Bears J. When can a clinical trial be called 'randomized'?. Vaccine 2003;21(5-6):468-72.

The following is a selected list of journal articles on randomized controlled trial. More information can be found from the books listed on the right box, articles in PubMed, or additional books from the UToledo Library Catalog.

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Bridgman S, Engebretsen L, Dainty K, Kirkley A, Maffulli N. Practical aspects of randomization and blinding in randomized clinical trials. Arthroscopy 2003;19(9):1000-6.
Berger V. A review of methods for ensuring the comparability of comparison groups in randomized clinical trials. Rev Recent Clin Trials 2006;1(1):81-6.
Cook J. The challenges faced in the design, conduct and analysis of surgical randomised controlled trials. Trials. 2009;10:9.
Curtis B, Barrett B, Parfrey P. The design of randomized controlled trials. Methods Mol Biol 2009;473:95-111
Donner A, Klar N. Pitfalls of and controversies in cluster randomization trials. Am J Public Health 2004;94(3):416-22.
Glasser S, Howard G. Clinical trial design issues: at least 10 things you should look for in clinical trials. J Clin Pharmacol 2006;46(10):1106-15.
Hallstrom A, Paradis N. Pre-randomization and de-randomization in emergency medical research: new names and rigorous criteria for old methods. Resuscitation 2005;65(1):65-9.
Hayes J. Problems with RCT design. Am J Orthod Dentofacial Orthop 2009;136(2):143-4; author reply 144-5.
Kroll T, Morris J. Challenges and opportunities in using mixed method designs in rehabilitation research. Arch Phys Med Rehabil 2009;90(11 Suppl):S11-6.
Murphy A, Esterman A, Pilotto L. Cluster randomized controlled trials in primary care: an introduction. Eur J Gen Pract 2006;12(2):70-3.
Onken J, Brazer S. Clinical trials. How should they be designed?. Gastrointest Endosc Clin N Am 1994;4(2):423-34.
Parfrey P, Ravani P. On framing the research question and choosing the appropriate research design. Methods Mol Biol 2009;473:1-17.
Rabeneck L, Viscoli C, Horwitz R. Problems in the conduct and analysis of randomized clinical trials. Are we getting the right answers to the wrong questions?. Arch Intern Med 1992;152(3):507-12
Rubinstein L, Crowley J, Ivy P, Leblanc M, Sargent D. Randomized phase II designs. Clin Cancer Res 2009;15(6):1883-90.
Shuster J. Design and analysis of experiments. Methods Mol Biol 2007;404:235-59.
Stone G, Pocock S. Randomized trials, statistics, and clinical inference. J Am Coll Cardiol 2010;55(5):428-31.
Vierron E, Giraudeau B. Design effect in multicenter studies: gain or loss of power?. BMC Med Res Methodol. 2009;9:39.